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DC13 co-supervisor

Prof. Christophe Hirtz

Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche en Cancérologie de Montpellier (IRCM), France

Pr. Christophe Hirtz has been working on Clinical Proteomics since 2000 and was one of the first to publish the complexity of the human salivary proteome (Hirtz et al., 2005) using mass spectrometry. Since then, he is specialized in clinical assays and R&D activities in the field of clinical proteomics and neurodegenerative diseases since 2010. He was technician between 1998 and 2007, then Engineer (2007-2009), associate professor (2009-2017) and then professor (2017-). He is recognized as an expert in high resolution proteomics for identification and quantification of biomarkers (Bottom-up/Top-down), in targeted mass spectrometry for multiplexed and absolute quantification of biomarkers, and in multiplexed and ultra-sensitive immunodetection. He is involved in the discovery, validation, and use of clinical biomarkers in many pathologies. He is coordinator of several academic projects including in 2019 a PRRI FEDER “SMART” funding (1000 K€), a France Alzheimer “Plasma Boost” funding (100K€) and participated in obtaining 4500 K€ of funding since 2011. He is currently responsible of the Clinical Proteomics Platform of Montpellier hospital and Montpellier University, part of the Shimadzu European Innovation Center and considered as a key opinion in the field of the clinical mass spectrometry. Christophe Hirtz is member of the « Société Française d’Electrophorèse et Analyse Protéomique (SFEAP) », member of the Joint Program – Neurodegenerative Disease (JPND), member of the European consortium EMPIR (15HLT04) NeuroMet and member of the European workgroup IFCC « development of a clinical MS-based reference system for standardization of multiple serum apolipoproteins ». He published more than 130 international scientific articles (H factor: 33, >4600 citations, 3 international patent) and obtained reward for Scientific Excellence (Montpellier University 2014-2018 and 2019-2023)

“Taking part in the European project MobiliTraIN is a chance to share knowledge, skills and expertise about Ion Mobility Mass Spectrometry potential. It’s the opportunity to participate to an international collaboration and exchange of ideas, knowledge, and expertise, fostering international cooperation.”

Selected Publications

  1. Relier S, Ripoll J, Guillorit H, Amalric A, Achour C, Boissière F, Vialaret J, Attina A, Debart F, Choquet A, Macari F, Marchand V, Motorin Y, Samalin E, Vasseur JJ, Pannequin J, Aguilo F, Lopez-Crapez E, Hirtz C, Rivals E, Bastide A, David A.FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell. Nat Commun. 2021 Mar 19;12(1):1716
  2. Pontier D, Picart C, El Baidouri M, Roudier F, Xu T, Lahmy S, Llauro C, Azevedo J, Laudié M, Attina A, Hirtz C, Carpentier MC, Shen L, Lagrange T The m6A pathway protects the transcriptome integrity by restricting RNA chimera formation in plants. . Life Sci Alliance. 2019 May 29;2(3):e201900393
  3. Lehmann S, Hirtz C, Vialaret J, Ory M, Combes GG, Corre ML, Badiou S, Cristol JP, Hanon O, Cornillot E, Bauchet L, Gabelle A, Colinge J. In Vivo Large-Scale Mapping of Protein Turnover in Human Cerebrospinal Fluid. Anal Chem. 2019 Dec 17;91(24):15500-15508
  4. Paterson RW, Gabelle A, Lucey BP, Barthélemy NR, Leckey CA, Hirtz C, Lehmann S, Sato C, Patterson BW, West T, Yarasheski K, Rohrer JD, Wildburger NC, Schott JM, Karch CM, Wray S, Miller TM, Elbert DL, Zetterberg H, Fox NC, Bateman RJ. SILK studies – capturing the turnover of proteins linked to neurodegenerative diseases. Nat Rev Neurol. 2019 Jul;15(7):419-427.
  5. Fortea J, Carmona-Iragui M, Benejam B, Fernández S, Videla L, Barroeta I, Alcolea D, Pegueroles J, Muñoz L, Belbin O, de Leon MJ, Maceski AM, Hirtz C, Clarimón J, Videla S, Delaby C, Lehmann S, Blesa R, Lleó A. Plasma and CSF biomarkers for the diagnosis of Alzheimer’s disease in adults with Down syndrome: a cross-sectional study. . Lancet Neurol. 2018 Oct;17(10):860-869.