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ORCID

BOKU

Assoc. Prof. Brigitte Gasser

University of Natural Resources and Life Sciences (BOKU), Institute of Microbiology and Microbial Biotechnology, Austria

DC 10 co-supervisor

Brigitte Gasser is Associate Professor for “Microbial Systems Biotechnology” at BOKU University (Vienna, Austria) and Head of the Area “Sustainable Production” at the Austrian Centre of Industrial Biotechnology (ACIB). She obtained her habilitation in “Yeast Molecular Biotechnology” in 2013 and her PhD in Biotechnology in 2007.

Her research focusses on systems and synthetic biology in the yeast Pichia pastoris (syn Komagataella phaffii), and on the design and development of improved cell factories and processes. Systems biology analyses including genome, transcriptome, proteome, metabolome, and fluxome analyses (performed in cooperation with the Institute of Analytical Chemistry at BOKU) provided valuable insights into cell physiology. Combining innovative cell and promoter engineering strategies with in vivo biosensors successfully enhanced secretion of industrially relevant recombinant proteins. In this field, Brigitte Gasser has published more than 100 papers, is inventor of 20 patent families, and received several prizes. She is editorial board member of Yeast, FEMS Yeast Research, and Microbial Cell Factories, and Commissioner at the International Yeast Commission ICY.

“I am very excited to co-supervise a talented DC in the MobiliTraIN network and develop new materials based on the biotechnologically relevant yeast Pichia pastoris as future measurement standards for ion mobility-mass spectrometry.”

Selected Publications

  1. Rebnegger C, Coltman BL, Kowarz V, Peña DA, Mentler A, Troyer C, Hann S, Schöny H, Koellensperger G, Mattanovich D, Gasser B. 2024. Protein production dynamics and physiological adaptation of recombinant Komagataella phaffii at near-zero growth rates. Microb Cell Fact. 23(1):43. doi: 10.1186/s12934-024-02314-3.
  2. Rebnegger C, Flores-Villegas M, Kowarz V, De S, Pusterla A, Holm H, Adelantado N, Kiziak C, Mattanovich D, Gasser B. 2024. Knock-out of the major regulator Flo8 in Komagataella phaffii results in unique host strain performance for methanol-free recombinant protein production. N Biotechnol. 84:105-114. doi: 10.1016/j.nbt.2024.10.001.
  3. Flores-Villegas M, Rebnegger C, Kowarz V, Prielhofer R, Mattanovich D, Gasser B. 2023. Systematic sequence engineering enhances the induction strength of the glucose-regulated GTH1 promoter of Komagataella phaffii. Nucleic Acids Res. 51(20):11358-11374. doi: 10.1093/nar/gkad752.
  4. Staudacher J, Rebnegger C, Dohnal T, Landes N, Mattanovich D, Gasser B. 2022. Going beyond the limit: Increasing global translation activity leads to increased productivity of recombinant secreted proteins in Pichia pastoris. Metab Eng. 70:181-195. doi: 10.1016/j.ymben.2022.01.010.
  5. Gassler T, Sauer M, Gasser B, Egermeier M, Troyer C, Causon T, Hann S, Mattanovich D, Steiger MG. 2020. The industrial yeast Pichia pastoris is converted from a heterotroph into an autotroph capable of growth on CO2. Nat Biotechnol. 38(2):210-216. doi: 10.1038/s41587-019-0363-0.
  6. Rußmayer H, Buchetics M, Gruber C, Valli M, Grillitsch K, Modarres G, Guerrasio R, Klavins K, Neubauer S, Drexler H, Steiger M, Troyer C, Al Chalabi A, Krebiehl G, Sonntag D, Zellnig G, Daum G, Graf AB, Altmann F, Koellensperger G, Hann S, Sauer M, Mattanovich D, Gasser B. 2015. Systems-level organization of yeast methylotrophic lifestyle. BMC Biol. 13:80. doi: 10.1186/s12915-015-0186-5.