Athina-Maria Zoi

DC3

Characterising and controlling internal energy in trapped ion mobility spectrometry, and its impact on structural chemistry, structural biology, and multi-omics

Bruker Daltonics GmbH & Co. KG (Bremen, Germany)

Background

Driven by a deep curiosity to understand and explain chemical processes, I earned a Bachelor of Science in Chemistry from the National and Kapodistrian University of Athens, Greece, graduating in September 2022. In addition to my studies, I gained hands-on experience at Gennimatas General Hospital in 2021, where I conducted biochemical and toxicological tests, drug level assessments, and capillary electrophoresis. During my academic journey, I became deeply interested in how human health is shaped by nutrition and the food we eat.

This passion led me to pursue a Master’s in Food Chemistry at the National and Kapodistrian University of Athens, Greece, which I completed in December 2024. My research focused on unravelling the metabolome alterations following acute wine consumption using High-Resolution Mass Spectrometry (HRMS). Through this work, I gained a deep understanding of the critical importance of increasing resolution in analytical techniques, enhancing the precision of the analysis and allowing for the identification of a broader range of molecules in complex samples. This experience deepened my interest in analytical chemistry and sparked my curiosity to explore ion mobility spectrometry, an emerging technology useful for compound identification, characterisation and quantification.

I am truly excited about joining the MobiliTraIN network. The opportunity to collaborate with researchers and institutions is particularly inspiring, as it will allow me to deepen my understanding of the fundamental principles underlying IM-HRMS. I am also eager to study effective temperature and heating in TIMS cells with the aim of characterising ion fragmentation and its causes, contributing to overcoming current challenges and enhancing the applicability of ion mobility spectrometry.

Secondments

University of Geneva (UNIGE)

Country: Switzerland

Duration: 3 months

Purpose: Controlling internal energy excitation for collision induced unfolding experiments

Universitäts Klinikum Jena (UKJ)

Country: Germany

Duration: 3 months

Purpose:Application of improved, low energy/soft MS methods on biologically relevant/clinical samples